Role of AHR in the control of GBM-associated myeloid cells
G Gabriely, FJ Quintana - Seminars in cancer biology, 2020 - Elsevier
G Gabriely, FJ Quintana
Seminars in cancer biology, 2020•ElsevierGlioblastoma (GBM) is an aggressive and incurable brain tumor; its malignancy has been
associated with the activity of tumor infiltrating myeloid cells. Myeloid cells play important
roles in the tumor control by the immune response, but also in tumor progression. Indeed,
GBM exploits multiple mechanisms to recruit and modulate myeloid cells. The Aryl
Hydrocarbon Receptor (AHR) is a ligand activated transcription factor implicated in the
regulation of myeloid cells. In this review, we will summarize current knowledge on the AHR …
associated with the activity of tumor infiltrating myeloid cells. Myeloid cells play important
roles in the tumor control by the immune response, but also in tumor progression. Indeed,
GBM exploits multiple mechanisms to recruit and modulate myeloid cells. The Aryl
Hydrocarbon Receptor (AHR) is a ligand activated transcription factor implicated in the
regulation of myeloid cells. In this review, we will summarize current knowledge on the AHR …
Abstract
Glioblastoma (GBM) is an aggressive and incurable brain tumor; its malignancy has been associated with the activity of tumor infiltrating myeloid cells. Myeloid cells play important roles in the tumor control by the immune response, but also in tumor progression. Indeed, GBM exploits multiple mechanisms to recruit and modulate myeloid cells. The Aryl Hydrocarbon Receptor (AHR) is a ligand activated transcription factor implicated in the regulation of myeloid cells. In this review, we will summarize current knowledge on the AHR role in the control of myeloid cells and its impact on GBM pathogenesis.
Elsevier
