Platelet activation biomarkers in Berkeley sickle cell mice and the response to prasugrel
K Ohno, H Tanaka, N Samata, JA Jakubowski… - Thrombosis …, 2014 - Elsevier
Vaso-occlusive crisis (VOC) is a common complication that occurs in sickle cell disease
(SCD) patients. Although underlying mechanisms of VOC remain unclear, platelet activation
has been associated with VOC. In the present study, plasma adenine nucleotide
measurements using LC-ESI-MS/MS showed that plasma ADP in the Berkeley murine
model of SCD was significantly higher (applox. 2.7-fold increase) compared with control
mice. Assessment of platelet activation markers using flow cytometry indicated that in SCD …
(SCD) patients. Although underlying mechanisms of VOC remain unclear, platelet activation
has been associated with VOC. In the present study, plasma adenine nucleotide
measurements using LC-ESI-MS/MS showed that plasma ADP in the Berkeley murine
model of SCD was significantly higher (applox. 2.7-fold increase) compared with control
mice. Assessment of platelet activation markers using flow cytometry indicated that in SCD …
